What Are The Fetal Chromosomal Factors That Cause Recurrent Miscarriage?

The experts indicated that embryo or fetal chromosome abnormality is the most common cause of early miscarriage, about 50% to 60% of recurrent miscarriage caused by embryo’s chromosome abnormality. The main causes of embryo chromosome abnormality are positive anti-embryo antibody (the index of anti-embryo antibody is greater than 1:64), abnormal intrauterine environment, such as mediastinum, fibroids, polyps and endocrine abnormalities; and then is the exposure to ionizing radiation, chemicals, microbial infections and heredity during pregnancy. 

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What is worth noticing is that chromosomal abnormalities that cause early recurrent miscarriage refer to embryo chromosomal abnormalities, not to conjugal-chromosome abnormalities, which occur in 99.99 percent of embryos where the couple’s chromosomes are normal; the embryo doesn’t necessarily have chromosome abnormality if one of the couple has a chromosome abnormality. The reason can only be known when the embryo is taken for chromosome culture after embryo arrest. 
 
And a couple of common chromosomal abnormalities will not lead to recurrent miscarriage, and chromosomal abnormalities are usually carry genotype, namely the mild chromosomal abnormalities, such as balanced translocation, inversion [46,XY,t(5,12)] etc. Its genetic information are not less, just chromosome fragment displacement occurs, such people’s gonads appears normal, so it won’t lead to recurrent miscarriage. At the best, the offspring born with the same chromosome as the precious generation. 

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